Document Type : Research Paper

Authors

1 Department of Psychology, Payame Noor University, Tehran, Iran,

2 Clinical Research Development Center of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Iran.

3 General Psychology, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

Abstract

Background and objective: Evidence has suggested that risk for schizophrenia is likely to occur in non-psychotic first-degree relatives of patients with schizophrenia. On the other hand, schizotypal personality disorder is genetically related to schizophrenia. The aim of this study was to compare schizotypal traits (i.e., positive schizotypy, negative schizotypy, cognitive disorganization, and impulsive nonconformity) among patients with schizophrenia and their non-psychotic first-degree relatives as well as normal controls. Methods: Thirty-four patients with schizophrenia and 50 of their non-psychotic first-degree relatives as well as 34 normal controls were included in this study. The data were collected by the Oxford-Liverpool Inventory of Feelings and Experiences, short version (sO-LIFE). Results: The results showed that the three groups were significantly different from each other regarding mean scores of schizotypal traits. Patients with schizophrenia and their non-psychotic first-degree relatives exceeded normal controls on schizotypal traits. Patients with schizophrenia had higher scores on total schizotypal traits, positive schizotypy, cognitive disorganization, and impulsive nonconformity than their non-psychotic first-degree relatives. Conclusion: The findings revealed that hereditary factors had an important role in the development of schizophrenia spectrum disorders and it is explainable by the stress-vulnerability model.

Keywords

Appels, M., Sitskoorn, M. M., Vollema, M. G., & Kahn, R. S. (2004). Elevated levels of schizotypal features in parents of patients with a family history of schizophrenia spectrum disorders. Schizophrenia bulletin, 30(4), 781.
Benjamini, Y., & Hochberg, Y. (2000). On the adaptive control of the false discovery rate in multiple testing with independent statistics. Journal of Educational and Behavioral Statistics, 25(1), 60-83.
Brosey, E., & Woodward, N. D. (2015). Schizotypy and clinical symptoms, cognitive function, and quality of life in individuals with a psychotic disorder. Schizophrenia research, 166(1), 92-97.
Calkins, M. E., Curtis, C. E., & Grove, W. M. (2004). Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patients. Schizophrenia bulletin, 30(2), 317.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976). Scales for physical and social anhedonia. Journal of abnormal psychology, 85(4), 374.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1978). Body-image aberration in schizophrenia. Journal of abnormal psychology, 87(4), 399.
Compton, M. T., & Broussard, B. (2009). The first episode of psychosis: A guide for patients and their families: Oxford University Press.
Debbané, M., Eliez, S., Badoud, D., Conus, P., Flückiger, R., & Schultze-Lutter, F. (2014). Developing psychosis and its risk states through the lens of schizotypy. Schizophrenia bulletin, 41(suppl_2), S396-S407.
Dudley, R., & Over, D. (2003). People with delusions jump to conclusions: A theoretical account of research findings on the reasoning of people with delusions. Clinical Psychology & Psychotherapy, 10(5), 263-274.
Etain, B., Roy, I., Henry, C., Rousseva, A., Schürhoff, F., Leboyer, M., & Bellivier, F. (2007). No evidence for physical anhedonia as a candidate symptom or an endophenotype in bipolar affective disorder. Bipolar disorders, 9(7), 706-712.
Ettinger, U., Mohr, C., Gooding, D. C., Cohen, A. S., Rapp, A., Haenschel, C., & Park, S. (2015). Cognition and brain function in schizotypy: a selective review. Schizophrenia bulletin, 41(suppl_2), S417-S426.
First, M., Spitzer, R. L., Gibbon, M., & Williams, J. B. (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition Biometrics Research. New York State Psychiatric Institute, New York.
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (2002). Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition.
Fisher, H. L., Caspi, A., Poulton, R., Meier, M. H., Houts, R., Harrington, H., . . . Moffitt, T. E. (2013). Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study. Psychological medicine, 43(10), 2077-2086.
Fonseca-Pedrero, E., Ortuño-Sierra, J., Sierro, G., Daniel, C., Cella, M., Preti, A., . . . Mason, O. (2015). The measurement invariance of schizotypy in Europe. European Psychiatry, 30(7), 837-844.
Fonseca Pedrero, E., & Debbané, M. (2017). Schizotypal traits and psychotic-like experiences during adolescence: an update. Psicothema, 29(1).
Freeman, D., Garety, P. A., Fowler, D., Kuipers, E., Bebbington, P. E., & Dunn, G. (2004). Why do people with delusions fail to choose more realistic explanations for their experiences? An empirical investigation. Journal of consulting and clinical psychology, 72(4), 671.
Freeman, D., Garety, P. A., Kuipers, E., Fowler, D., & Bebbington, P. E. (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology, 41(4), 331-347.
Garety, P. A., Kuipers, E., Fowler, D., Freeman, D., & Bebbington, P. (2001). A cognitive model of the positive symptoms of psychosis. Psychological medicine, 31(2), 189-195.
Ghamari Givi, H., Moulavi, P., & Heshmati, R. (2010). Exploration of the Factor Structure of Positive and Negative Syndrome Scale in Schizophernia Spectrum Disorder. Journal of Clinical Psychology, 2(2), 1-10.
Goldberg, D., & Williams, P. (2000). General health questionnaire (GHQ). Swindon, Wiltshire, UK: nferNelson.
Goulding, A. (2004). Schizotypy models in relation to subjective health and paranormal beliefs and experiences. Personality and individual differences, 37(1), 157-167.
Hajnal, A., Tényi, T., Varga, E., Simon, M., Halmai, T., Németh, N., . . . Herold, R. (2014). Social cognitive differences in first-degree relatives of patients with schizophrenia. A systematic review. Psychiatria Hungarica: A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata, 29(3), 301-307.
Horan, W. P., Reise, S. P., Subotnik, K. L., Ventura, J., & Nuechterlein, K. H. (2008). The validity of Psychosis Proneness Scales as vulnerability indicators in recent-onset schizophrenia patients. Schizophrenia research, 100(1), 224-236.
Kay, S. R., Fiszbein, A., & Opfer, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia bulletin, 13(2), 261.
Kinderman, P. (2005). A psychological model of mental disorder. Harvard review of psychiatry, 13(4), 206-217.
Kwapil, T. R., & Barrantes-Vidal, N. (2014). Schizotypy: looking back and moving forward. Schizophrenia bulletin, 41(suppl_2), S366-S373.
Laurent, A., Biloa-Tang, M., Bougerol, T., Duly, D., Anchisi, A.-M., Bosson, J.-L., . . . Dalery, J. (2000). Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophrenia research, 46(2), 269-283.
Lenzenweger, M. F. (2011). Schizotypy and schizophrenia: The view from experimental psychopathology: Guilford Press.
Linney, Y., Murray, R., Peters, E., MacDonald, A., Rijsdijk, F., & Sham, P. (2003). A quantitative genetic analysis of schizotypal personality traits. Psychological medicine, 33(5), 803-816.
Mason, O., Linney, Y., & Claridge, G. (2005). Short scales for measuring schizotypy. Schizophrenia research, 78(2), 293-296.
Mata, I., Sham, P. C., Gilvarry, C. M., Jones, P. B., Lewis, S. W., & Murray, R. M. (2000). Childhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relatives. Schizophrenia research, 44(2), 129-136.
Moreno-Izco, L., Sánchez-Torres, A. M., Lorente-Omeñaca, R., Fañanás, L., Rosa, A., Salvatore, P., . . . Cuesta, M. J. (2015). Ten-year stability of self-reported schizotypal personality features in patients with psychosis and their healthy siblings. Psychiatry research, 227(2), 283-289.
Nazifi, M., Mokarami, H., Akbaritabar, A., Faraji Kujerdi, M., Tabrizi, R., & Rahi, A. (2014). Reliability, Validity and Factor Structure of the Persian Translation of General Health Questionnaire (GHQ-28) in Hospitals of Kerman University of Medical Sciences. Journal of Fasa University of Medical Sciences/Majallah-i Danishgah-i Ulum-i Pizishki-i Fasa, 3(4).
Nicolson, R., Brookner, F. B., Lenane, M., Gochman, P., Ingraham, L. J., Egan, M. F., . . . Rapoport, J. L. (2003). Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia. American Journal of Psychiatry, 160(3), 490-495.
Onstad, S., Skre, I., Edvardsen, J., Torgersen, S., & Kringlen, E. (1991). Mental disorders in first‐degree relatives of schizophrenics. Acta Psychiatrica Scandinavica, 83(6), 463-467.
Raine, A. (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia bulletin, 17(4), 555.
Raine, A., & Benishay, D. (1995). The SPQ-B: a brief screening instrument for schizotypal personality disorder. Journal of personality disorders, 9(4), 346-355.
Rossi, A., & Daneluzzo, E. (2002). Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples. Schizophrenia research, 54(1), 67-75.
Schürhoff, F., Laguerre, A., Szöke, A., Méary, A., & Leboyer, M. (2005). Schizotypal dimensions: continuity between schizophrenia and bipolar disorders. Schizophrenia research, 80(2), 235-242.
Schürhoff, F., Szöke, A., Bellivier, F., Turcas, C., Villemur, M., Tignol, J., . . . Leboyer, M. (2003). Anhedonia in schizophrenia: a distinct familial subtype? Schizophrenia research, 61(1), 59-66.
Sierro, G., Rossier, J., Mason, O. J., & Mohr, C. (2015). French validation of the O-LIFE short questionnaire. European Journal of Psychological Assessment.
Solanki, R., Swami, M. K., Singh, P., & Gupta, S. (2012). Identification of vulnerability among first-degree relatives of patients with schizophrenia. East Asian Archives of Psychiatry, 22(3), 118.
Sterling, M. (2011). General health questionnaire–28 (GHQ-28). Journal of physiotherapy, 57(4), 259.
Torgersen, S., Edvardsen, J., Øien, P., Onstad, S., Skre, I., Lygren, S., & Kringlen, E. (2002). Schizotypal personality disorder inside and outside the schizophrenic spectrum. Schizophrenia research, 54(1), 33-38.
Tsuang, M. T., Stone, W. S., Tarbox, S. I., & Faraone, S. V. (2002). An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention. Schizophrenia research, 54(1), 169-175.
van Kampen, D. (2006). The Schizotypic Syndrome Questionnaire (SSQ): psychometrics, validation and norms. Schizophrenia research, 84(2), 305-322.
Van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009). A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorder. Psychological medicine, 39(2), 179-195.
Wolfradt, U., & Straube, E. R. (1998). Factor structure of schizotypal traits among adolescents. Personality and individual differences, 24(2), 201-206.
Woodward, N. D., Cowan, R. L., Park, S., Ansari, M. S., Baldwin, R. M., Li, R., . . . Zald, D. H. (2011). Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions. American Journal of Psychiatry, 168(4), 418-426.
Yaghoubi, H., & Mohammadzadeh, A. (2012). Validation of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) Questionnaire. Zahedan Journal of Research in Medical Sciences, 14(9), 24-29.
Zubin, J., & Spring, B. (1977). Vulnerability: a new view of schizophrenia. Journal of abnormal psychology, 86(2), 103.
 Zhao, Z. (2016). A Cross-Cultural Comparison of Schizotypy and Social Trait Judgments (Doctoral dissertation, Vanderbilt University).
Walter, E. E., Fernandez, F., Snelling, M., & Barkus, E. (2016). Genetic consideration of schizotypal traits: A review. Frontiers in psychology, 7, 1769.
Rudnick, A., & Lundberg, E. (2012). The stress-vulnerability model of schizophrenia: A conceptual analysis and selective review. Current Psychiatry Reviews, 8(4), 337-341.