Background: The aim of this study was to compare three clinical inventions such as drug therapy alone, with drug therapy combination to Cognitive behavior therapy, and drug therapy with yoga intervention, on major depression and general anxiety.

Methods: This research has been performed with semi-experimental method by pre-test post-test, and follow up design. The statistical sample include of 79 patients with major depression plus general anxiety disorder from Taleghany hospital of Ilam city, were selected through available method. These patients were divided into 3 intervention groups (22 patients were exposed to drug therapy, only. 29 patients were exposed to drug therapy plus cognitive-behavioral therapy group, and finally 28 patients were exposed to drug therapy plus Yoga). Patients were evaluated in three pre-posttest and follow-up phases by psychiatric interview, Beck depressive inventory (BDI), and Beck Anxiety Inventory (BAI). collected data were analyzed with repeated measure test in SPSS.

Results: The result showed that the patients who had practiced Yoga plus drug therapy were improved more than drug therapy alone, and drug therapy plus cognitive behavior therapy. In addition, cognitive behavior therapy in combination with drug therapy, was effective than drug therapy alone. Therefore, Yoga as a complementary therapy in combination with drug therapy could reduce symptoms of major-depression, and general anxiety disorder, significantly. Also the significant difference of yoga and cognitive behavior therapy with drug therapy alone, on major-depression, and general anxiety disorder, were permanently in follow-up at six months’ period.

Conclusion: According to this results, we can recommend, yoga interventions as a complementary therapy, in addition to drug therapy alone, and cognitive behavioral therapy for patients with major depression and general anxiety disorders.