Clinical Psychology Studies

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

reviwers 2021

reviwers 2022

Comparison of senile executive function with Down syndrome with and without Alzheimer's disorder

Document Type : Research Paper

Authors

1 P.h.d in psychology and education of exceptional children. Scince and Research Branch, Islamic Azad University, Tehran, Iran.

2 Associatet Prpfessor, Department of psychology and education of exceptional children, University of Tehran, Tehran, Iran

3 Professor, Department of Educational Psychology and education of exceptional children, University of Tehran, Tehran, Iran.

Abstract

Objective: Studies have shown that Alzheimer's progression in people with Down syndrome is associated with a faster disorder in some of the functional functions. The purpose of this study was to compare the performance of adults with Down syndrome with and without Alzheimer's disorder. Method: The present study is a causal-comparative study. The statistical population of the study consisted of all subjects with Down syndrome over 40 years of age and included 10 subjects or Down syndrome with Alzheimer's disorder and 10 subjects with Down syndrome without Alzheimer's disorder (a total of 20 people), which were selected by availability and then by instrument Wisconsin Cards and Stroop Test. MANOVA was used to compare the groups. Results: The results of the analysis of the data showed that among people with Down syndrome with Alzheimer's with people with Down syndrome without Alzheimer's There is a significant difference between Wisconsin and Stroup tests. Conclusion: The results showed that people with Down syndrome with Alzheimer's had a weaker performance than the other group. In fact, reducing the size of the cognitive reservoir in the frontal lobe leads to early impairment and then signs of impairment in the functional functions.

Keywords

References
افروز ، غلامعلی (1393). روان شناسی و توان بخشی کودکان و توجوانان سندرم دوان ، انتشارات دانشگاه تهران ، چاپ هشتم.
افروز، غلامعلی. (1384). کودکان و نوجوانان آهسته­گام در نگاه والدین و معلمان. انتشارات موسسه احیای کودکان استثنایی.
صادقی، عباس؛ افروز، غلامعلی، قره گزلی، کوروش، شریفی درآمدی، پرویز. (1392).بررسی تحلیلی و مقایسه­ای ویژگی­های شناختی بزرگسالان با نشانگان داون با اختلال آلزایمر و بدون اختلال آلزایمر همراه با گامی در تدوین استراتژی پیشگیری.
علیلو، م. م.، حمیدی، ص.، شیروانی، ا.، (1390).مقایسه کارکردهای اجرایی و توجه پایدار در دانشجویان دارای علایم وسواسی- اجباری، اسکیزوتایپی بالا و علایم همپوش با گروه بهنجار. تحقیقات علوم رفتاری، 9(3)، 221-216.
نادری،نسرین. (1373). بررسی پردازش اطلاعات و برخی از عملکردهای نوروپسیکولوژی مبتلایان به اختلال وسواسی فکری -عملی. پایان نامه کارشناسی ارشد روانشناسی بالینی، انستیتو روان پزشکی تهران.
نجاتی، وحید. (1388). کارکردهای شناختی- اجرایی قطعه پیشانی مغز در سالمندان. مجله علوم رفتاری، 4(3)، 59-64.
 
Adams, D., & Oliver, C. (2010). The relationship between acquired impairments of executive function and behaviour change in adults with down syndrome. Journal of Intellectual Disability Research, 54, 393–405.
Carr J, Collins S. (2014( Ageing and dementia in a longitudinal study of a cohort with Down syndrome. J Appl Res Intellect Disabil;27:555–563.
Costanzo, F., Varuzza, C., Menghini, D., Addona, F., Gianesini, T., and Vicari, S. (2013). Executive functions in intellectual disabilities: a comparison between Williams syndrome and Down syndrome. Res. Dev. Disabil. 34, 1770–1780. doi: 10.1016/j.ridd.2013.01.024
Dekker, A. D., Strydom, A., Coppus, A. M., Nizetic, D., Vermeiren, Y., Naudé, P. J., et al. (2015). Behavioural and psychological symptoms of dementia in down syndrome: early indicators of clinical Alzheimer's disease? Cortex, 73, 36–61.
De Vreese LP, Gomiero T, Uberti M, Bastiani, Ede, Weger E, Mantesso U, Marangoni A. (2015). Functional abilities and cognitive decline in adult and aging intellectual disabilities. Psychometric validation of an Italian version of the Alzheimer’s Function Assessment Tool (AFAST): analysis of its clinical significance with linear statistics and artificial neural networks. J Intellect Disabil Res;59:370–384.
Ersche, K. D., Turton, A. J., Chamberlain, S. R., Müller, U., Bullmore, E. T., and Robbins, T. W. (2012). Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence. Am. J. Psychiatry 169, 926–936. doi: 10.1176/appi.ajp.2012.11091421
Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., et al. (2014). Down syndrome and Alzheimer's disease: common pathways, common goals. Alzheimer's & Dementia, 1–10.
Hanney M, Prasher V, Williams N, Jones EL, Corbett A, Lawrence D, Yu LM, Tyrer S, Francis PT, Johnson T, Bullok R.( 2012). MEADOWS trial researchers: Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomized, double-blind, placebo-controlled trial. Lancet;379:528–536.
Head E, Powell D, Gold BT, Schmitt FA.( 2012). Alzheimer’s Disease in DS. Eur J Neurodegener Dis;1:353–64.
Iacono, T., Torr, J., and Wong, H. Y. (2010). Relationships amongst age, language and related skills in adults with Down syndrome. Res. Dev. Disabil. 31, 568–576. doi: 10.1016/j.ridd.2009.12.009
Megarbane, A., Ravel, A., Mircher, C., Sturtz, F., Grattau, Y., Rethore, M. O., et al. (2009). The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet. Med. 11, 611–616. doi: 10.1097/GIM.0b013e3181b2e34c.
McCarron M, McCallion P, Reilly E, Mulryan N. (2014).A prospective 14-year longitudinal follow up of dementia in persons with Down syndrome. J Intellect Disabil Res;58:61–70.
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7(3), 263–269.
Nho K, Risacher SL, Crane PK, DeCarli C, Glymour MM, Habeck C, et al. (2012).Alzheimer’s Disease Neuroimaging Initiative–ADNI. Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer’s disease. Brain Imaging Behav;6:551–67.
Pennington, B. F., Moon, J., Edgin, J., Stedron, J., and Nadel, L. (2003). The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child Dev. 74, 75–93. doi: 10.1111/1467-8624.00522
Rowe, J., Lavender, A., and Turk, V. (2006). Cognitive executive function in Down’s syndrome. Br. J. Clin. Psychol. 45, 5–17. doi: 10.1348/014466505X29594.
Smits LL, Tijms BM, Benedictus MR, Koedam EL, Koene T, Reuling IE, et al (2014). Regional atrophy is associated with impairment in distinct cognitive domains in Alzheimer’s disease. Alzheimers Dement;10(5 Suppl):S299–305.
Strydom, A., Shooshtari, S., Lee, L., Raykar, V., Torr, J., Tsiouris, J., et al. (2010). Dementia in older adults with intellectual disabilities—epidemiology, presentation, and diagnosis. Journal of Policy and Practice in Intellectual Disabilities, 7(2), 96–110.
Vicari, S. (2006). Motor development and neuropsychological patterns in persons with Down syndrome. Behav. Genet. 36, 355–364. doi: 10.1007/s10519-006- 9057-8
Willoughby, M. T., Wirth, R. J., & Blair, C. B. (2011). Contributions of modern measurement theory to measuring executive function in early childhood: An empirical demonstration. Journal of Experimental Child Psychology, 108, 414-435.
Clinical Psychology Studies
Volume 9, Issue 32
September 2018
Pages 113-125
Files
Share
How to cite
Statistics